منابع مشابه
Estrogen turns down "the AIRE".
Genetic alterations are known drivers of autoimmune disease; however, there is a much higher incidence of autoimmunity in women, implicating sex-specific factors in disease development. The autoimmune regulator (AIRE) gene contributes to the maintenance of central tolerance, and complete loss of AIRE function results in the development of autoimmune polyendocrinopathy syndrome type 1. In this i...
متن کاملFAA turns down the volume.
Administration (FAA), air traffic is expected to double nationally by the year 2017. Increased air traffic also means an increase in airplane noise. To help regulate the impact of noise on the environment, the FAA established the Airport Noise and Capacity Act in 1990, which required all civil jet aircraft over 75,000 pounds to reduce noise and lessen their environmental effects overall by 1 Ja...
متن کاملThe AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus
BACKGROUND The autoimmune regulator (AIRE) is expressed in the thymus, particularly in thymic medullary epithelial cells (mTECs), and is required for the ectopic expression of a diverse range of peripheral tissue antigens by mTECs, facilitating their ability to perform negative selection of auto-reactive immature T-cells. The expression profile of peripheral tissue antigens is affected not only...
متن کاملAire.
Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECED have revealed that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting ectopic expression of a large repertoire of transcripts encoding proteins normally restricted to differentiated organs residing in t...
متن کاملHow the Brain Turns Down the Volume on Your Noisy Body
Dr. Sawtell, who is also professor of neuroscience at Columbia University Medical Center, and his team have largely tackled this issue using an unusual model system — a species of electric fish, called the elephantnose fish, from Africa that both generates and senses electricity. Their studies have revealed important insights into how circuits in the brains of these fish distinguish behaviorall...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci86800